Article
Targeted ablation of pituitary gonadotropes in transgenic mice.
Molecular endocrinology (Baltimore, Md.) - 1 Dec 1991
Kendall S K, Saunders T L, Jin L, Lloyd R V, Glode L M, Nett T M, Keri R A, Nilson J H, Camper S A
Abstract excerpt
LH, FSH, and TSH are heterodimeric glycoprotein hormones composed of a common alpha-subunit and unique beta-subunits. The alpha-subunit is produced in two distinct specialized cell types of the pituitary gland: gonadotropes, which synthesize LH and FSH, and thyrotropes, which synthesize TSH. We have demonstrated that 313 base pairs of the bovine-alpha subunit promoter direct expression of diphtheria toxin A chain...
Topics
- Adrenocorticotropic Hormone
- Animals
- Base Sequence
- Cell Death
- Cell Differentiation
- Diphtheria Toxin
- Female
- Follicle Stimulating Hormone
- Growth Hormone
- Homozygote
- Hypogonadism