Article
Efficient Identification of Null-Allele Single Nucleotide Polymorphism Markers.
Human heredity - 1 Jan 2015
Özbek Umut, Feingold Eleanor, Weeks Daniel E
Abstract excerpt
OBJECTIVES: At the beginning of a genome-wide association study, many markers are discarded because they fail to meet standard quality control criteria. Some of these markers are out of Hardy-Weinberg equilibrium (HWE) because they have 'null alleles' (which may be deletions or third alleles that do not hybridize to standard probes). It may be useful to identify null-allele markers so that they can be analyzed...
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