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Article

Progressive cardiac conduction defect is the prevailing phenotype in carriers of a Brugada syndrome SCN5A mutation.

Journal of cardiovascular electrophysiology - 1 Mar 2006

Probst Vincent, Allouis Marie, Sacher Frederic, Pattier Sabine, Babuty Dominique, Mabo Philipe, Mansourati Jacques, Victor Jacques, Nguyen Jean-Michel, Schott Jean-Jacques, Boisseau Pierre, Escande Denis, Le Marec Hervé

Abstract excerpt

INTRODUCTION: Loss-of-function mutations in the SCN5A gene encoding the cardiac sodium channel are responsible for Brugada syndrome (BS) and also for progressive cardiac conduction disease (inherited Lenègre disease). In an attempt to clarify the frontier between these two entities, we have characterized cardiac conduction defect and its evolution with aging in a cohort of 78 patients carrying a SCN5A mutation...

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Identifiers

PMID: 16643399
DOI: 10.1111/j.1540-8167.2006.00349.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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