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Article

Establishment of permanent renal tubule cell lines by infection with the wild-type and a thermosensitive mutant of the simian virus 40.

American journal of kidney diseases : the official journal of the National Kidney Foundation - 1 Jun 1991

Vandewalle A, Ronco P, Cassingena R

Abstract excerpt

This study summarizes the properties of rabbit renal tubule cell lines transformed by the simian virus 40 (SV40). By infection with the wild type SV40, it was possible to establish three different cell lines exhibiting the main functions of proximal (RC.SV1), thick ascending limb-distal (RC.SV2), and collecting (RC.SV3) tubules. Another cell line infected with a thermosensitive mutant of SV40 (RC.SVtsA58) was...

Topics

Animals
Cell Line, Transformed
Cell Transformation, Viral
Culture Media
Cytological Techniques
Kidney Tubules
Mutation
Phenotype
Rabbits
Simian virus 40
Temperature

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 1645927
DOI: 10.1016/s0272-6386(12)80334-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1645927-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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