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Article

Characterization of native retinal fluorophores involved in biosynthesis of A2E and lipofuscin-associated retinopathies.

The Journal of biological chemistry - 30 Jun 2006

Bui Tam V, Han Yun, Radu Roxana A, Travis Gabriel H, Mata Nathan L

Abstract excerpt

Mutations in the photoreceptor-specific ABCA4 gene are associated with several inherited retinal and macular degenerations. A prominent phenotype of these diseases is the accumulation of cytotoxic lipofuscin fluorophores such as A2E within the retinal pigment epithelium. Another compound, dihydro-N-retinylidene-N-retinylphosphatidyl-ethanolamine (A2PE-H(2)), also accumulates in retinas of mice and humans...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16638746
DOI: 10.1074/jbc.M601380200

Genes

ABCA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Characterization of native retinal fluorophores involved in biosynthesis of A2E and lipofuscin-associated retinopathies.PMID 16638746Read ↗

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