Article
Insights into the function of Rim protein in photoreceptors and etiology of Stargardt's disease from the phenotype in abcr knockout mice.
Cell - 9 Jul 1999
Weng J, Mata N L, Azarian S M, Tzekov R T, Birch D G, Travis G H
Abstract excerpt
Rim protein (RmP) is an ABC transporter of unknown function in rod outer segment discs. The human gene for RmP (ABCR) is affected in several recessive retinal degenerations. Here, we characterize the ocular phenotype in abcr knockout mice. Mice lacking RmP show delayed dark adaptation, increased all-trans-retinaldehyde (all-trans-RAL) following light exposure, elevated phosphatidylethanolamine (PE) in outer...
Topics
- ATP-Binding Cassette Transporters
- Adaptation, Ocular
- Animals
- Darkness
- Electroretinography
- Genomic Library
- Humans
- Macular Degeneration
- Metabolic Clearance Rate
- Mice
- Mice, Knockout
- Phenotype
- Phospholipids
- Retina
- Retinaldehyde