Article
Oxidative radicals and liver involvement of infants with alpha-1-antitrypsin deficiency.
Padiatrie und Padologie - 1 Jan 1991
Pittschieler K
Abstract excerpt
Low levels of alpha-1-antitrypsin can predispose deficient infants to the development of hepatitis and cirrhosis. Heterozygous PiMZ carriers can be affected by a subclinical liver involvement during their first half year of life. One pathogenic hypothesis of liver damage is that the process seems to be mediated by the activity of toxic oxygen waste products. In the present investigation it was found that the...
Topics
- Free Radicals
- Hepatitis
- Heterozygote
- Homozygote
- Humans
- Hydrogen Peroxide
- Infant
- Liver Function Tests
- Phenotype
- Superoxides
- Vitamin E
- alpha 1-Antitrypsin