Liver disease and heterozygous alpha-1-antitrypsin deficiency.

Abstract excerpt

From 1985 to 1988 14,938 newborns were screened during the first days of life to determine their protease inhibitor phenotype (Pi) and 467 PiMZ and 456 PiMS were identified. Of these 101 PiMZ and 135 PiMS were followed-up and their clinical, biochemical and, in selected cases, histological data were recorded at two, five and twelve months of age. Nineteen out of 101 PiMZ infants showed hepatic dysfunction at two...

Topics

• Biopsy
• Heterozygote
• Humans
• Infant, Newborn
• Liver Diseases
• Liver Function Tests
• Neonatal Screening
• Phenotype
• alpha 1-Antitrypsin