Article
Pathomechanisms of type 2 diabetes genes.
Endocrine reviews - 1 Oct 2009
Staiger Harald, Machicao Fausto, Fritsche Andreas, Häring Hans-Ulrich
Abstract excerpt
Type 2 diabetes mellitus is a complex metabolic disease that is caused by insulin resistance and beta-cell dysfunction. Furthermore, type 2 diabetes has an evident genetic component and represents a polygenic disease. During the last decade, considerable progress was made in the identification of type 2 diabetes risk genes. This was crucially influenced by the development of affordable high-density single...
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