Article
Effects of glutathione S-transferase A1 (GSTA1) genotype and potential modifiers on breast cancer risk.
Carcinogenesis - 1 Sept 2006
Ahn Jiyoung, Gammon Marilie D, Santella Regina M, Gaudet Mia M, Britton Julie A, Teitelbaum Susan L, Terry Mary Beth, Neugut Alfred I, Eng Sybil M, Zhang Yuesheng, Garza Cutberto, Ambrosone Christine B
Abstract excerpt
Glutathione S-transferases (GSTs) are phase II enzymes that are involved in the detoxification of a wide range of carcinogens. The novel GSTA1*A and GSTA1*B genetic polymorphism results in differential expression, with lower transcriptional activation of GSTA1*B (variant) than that of GSTA1*A (common) allele. Considering that cruciferous vegetables induce GSTs, which metabolize tobacco smoke carcinogens, we...
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