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Article

Escape from hsa-miR-519c enables drug-resistant cells to maintain high expression of ABCG2

1 Oct 2009

Abstract excerpt

Overexpression of ABCG2 has been reported in cell lines selected for drug resistance and it is widely believed to be important in the clinical pharmacology of anticancer drugs. We and others have previously identified and validated two microRNAs (miRNA; hsa-miR-519c and hsa-miR-520h) targeting ABCG2. In this study, the shortening of the ABCG2 3' untranslated region (3'UTR) was found to be a common phenomenon in...

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PMID: 19825807
DOI: 10.1158/1535-7163.mct-09-0292

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