Patients with Hereditary Hemorrhagic Telangectasia (HHT) exhibit a deficit of polymorphonuclear cell and monocyte oxidative burst and phagocytosis: a possible correlation with altered adaptive immune responsiveness in HHT.

doi:10.2174/138161206776361336

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Article

Patients with Hereditary Hemorrhagic Telangectasia (HHT) exhibit a deficit of polymorphonuclear cell and monocyte oxidative burst and phagocytosis: a possible correlation with altered adaptive immune responsiveness in HHT.

Current pharmaceutical design - 1 Jan 2006

Cirulli Anna, Loria Maria Paola, Dambra Porzia, Di Serio Francesca, Ventura Maria T, Amati Luigi, Jirillo Emilio, Sabbà Carlo

Abstract excerpt

Hereditary Hemorrhagic Telangiectasia (HHT) is a rare genetic disease characterized by mutations occurring in the endoglin and ALK-1, two receptors of transforming growth factor-beta1. From a pathogenic point of view, a possible involvement of the immune system in HHT has been suggested since a mononuclear cell infiltrate was found around the area of telangiectases. Up until now, no information has been available...

Topics

Adult
Aged
B-Lymphocytes
Female
Humans
Immunoglobulin A
Immunoglobulin G
Immunoglobulin M
Killer Cells, Natural
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Monocytes

Neutrophils

Phagocytosis

Phenotype

Reproducibility of Results

Respiratory Burst

T-Lymphocytes

Source

Open in PubMed

Identifiers

PMID: 16611102
DOI: 10.2174/138161206776361336

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