Article
Restenosis after percutaneous coronary intervention is associated with the angiotensin-II type-1 receptor 1166A/C polymorphism but not with polymorphisms of angiotensin-converting enzyme, angiotensin-II receptor, angiotensinogen or heme oxygenase-1.
Pharmacogenetics and genomics - 1 May 2006
Wijpkema Jasper S, van Haelst Paul L, Monraats Pascalle S, Bruinenberg Marcel, Zwinderman Aeilko H, Zijlstra Felix, van der Steege Gerrit, de Winter Rob J, Doevendans Pieter A F M, Waltenberger Johannes, Jukema J Wouter, Tio René A
Abstract excerpt
OBJECTIVES: The renin-angiotensin system (RAS) is thought to play a major role in the pathophysiology of de-novo restenotic lesions and in-stent restenosis after percutaneous coronary intervention (PCI). Heme oxygenase-1 (HO-1), is thought to beneficially influence these processes. We examined the effect of pharmacologic as well as genetic RAS interactions on restenosis in a large population of consecutive...
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