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Article

Analysis of human telomerase activity and function by two color single molecule coincidence fluorescence spectroscopy.

Journal of the American Chemical Society - 19 Apr 2006

Ren Xiaojun, Li Haitao, Clarke Richard W, Alves David A, Ying Liming, Klenerman David, Balasubramanian Shankar

Abstract excerpt

Telomerase is a nonclassical DNA polymerase that uses its integral RNA as a template to synthesize telomeric repeats onto chromosome ends. The molecular mechanism of telomerase is unique and involves a translocation step after the synthesis of each telomeric repeat. To directly measure the enzymatic turnover of substrate and the efficiency of the translocation step we have extended our two-color single molecule...

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Identifiers

PMID: 16608333
DOI: 10.1021/ja056613z
PMCID: PMC2195889

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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