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Article

Single-molecule analysis of the human telomerase RNA.dyskerin interaction and the effect of dyskeratosis congenita mutations.

Biochemistry - 24 Nov 2009

Ashbridge Beth, Orte Angel, Yeoman Justin A, Kirwan Michael, Vulliamy Tom, Dokal Inderjeet, Klenerman David, Balasubramanian Shankar

Abstract excerpt

It has been proposed that human telomerase RNA (hTR) interacts with dyskerin, prior to assembly of the telomerase holoenzyme. The direct interaction of dyskerin and hTR has not been demonstrated and is an experimentally challenging research problem because of difficulties in expressing and purifying dyskerin in quantities that are useful for biophysical analysis. By orthogonally labeling dyskerin and hTR, we have...

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Identifiers

PMID: 19835419
DOI: 10.1021/bi901373e
PMCID: PMC2778356

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Single-molecule analysis of the human telomerase RNA.dyskerin interaction and the effect of dyskeratosis congenita mutations.PMID 19835419Read ↗

N-terminal residues of human dyskerin are required for interactions with telomerase RNA that prevent RNA degradationSemantic proximity Read ↗

The C-terminal extension of dyskerin is a dyskeratosis congenita mutational hotspot that modulates interaction with telomerase RNA and subcellular localization.Semantic proximity Read ↗

Disease mutations in the N-terminal extension and α2’-helix of dyskerin do not abolish dimerization but disrupt binding to the telomerase RNASemantic proximity Read ↗

Disease mutations in the N-terminal extension and α2’-helix of dyskerin do not abolish dimerization but disrupt binding to the telomerase RNASemantic proximity Read ↗

Telomerase RNA structure and function: implications for dyskeratosis congenita.Semantic proximity Read ↗

Dyskeratosis congenita.Semantic proximity Read ↗

A telomerase component is defective in the human disease dyskeratosis congenitaSemantic proximity Read ↗

Dyskeratosis congenita mutations in dyskerin SUMOylation consensus sites lead to impaired telomerase RNA accumulation and telomere defects.Semantic proximity Read ↗

Disease-associated human telomerase RNA variants show loss of function for telomere synthesis without dominant-negative interference.Semantic proximity Read ↗

Effects of dyskeratosis congenita mutations in dyskerin, NHP2 and NOP10 on assembly of H/ACA pre-RNPs.Semantic proximity Read ↗

The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita.Semantic proximity Read ↗

YNMG tetraloop formation by a dyskeratosis congenita mutation in human telomerase RNA.Semantic proximity Read ↗

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