Article
CBHA is a family of hybrid polar compounds that inhibit histone deacetylase, and induces growth inhibition, cell cycle arrest and apoptosis in human endometrial and ovarian cancer cells.
Oncology - 1 Jan 2006
Takai Noriyuki, Ueda Tami, Nishida Masakazu, Nasu Kaei, Matsuda Kaho, Kusumoto Mamiko, Narahara Hisashi
Abstract excerpt
OBJECTIVES: We investigated the effect of a novel synthesized histone deacetylase inhibitor (HDACI), CBHA, on three endometrial cancer cell lines, two ovarian cancer cell lines, and normal human endometrial epithelial cells. METHODS: Endometrial and ovarian cancer cells were treated with various concentrations of CBHA, and its effect on cell growth, cell cycle, apoptosis, and related measurements was...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.