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Article

Trisomy 21: from chromosomes to mental retardation.

Behavior genetics - 1 May 2006

Roubertoux Pierre L, Kerdelhué Bernard

Abstract excerpt

The first descriptions of the trisomy 21 phenotype were by Jean-Etienne-Dominique Esquirol (1838), Edouard Séguin (1846) and later by John L. H. Down in 1862. It took more than a century to discover the extra-chromosomal origin of the syndrome commonly called "Down's syndrome" and which, we suggest, should be referred to as "Trisomy 21". In this review we are presenting the landmarks, from the pioneering...

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Identifiers

PMID: 16596471
DOI: 10.1007/s10519-006-9052-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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