Article
CD4+CD25+ T cells in skin lesions of patients with cutaneous leishmaniasis exhibit phenotypic and functional characteristics of natural regulatory T cells.
The Journal of infectious diseases - 1 May 2006
Campanelli Ana P, Roselino Ana M, Cavassani Karen A, Pereira Marcelo S F, Mortara Renato A, Brodskyn Claudia I, Goncalves Heitor S, Belkaid Yasmine, Barral-Netto Manoel, Barral Aldina, Silva Joao S
Abstract excerpt
Endogenous regulatory T (Treg) cells are involved in the control of infections, including Leishmania infection in mice. Leishmania viannia braziliensis is the main etiologic agent of cutaneous leishmaniasis (CL) in Brazil, and it is also responsible for the more severe mucocutaneous form. Here, we investigated the possible involvement of Treg cells in the control of the immune response in human skin lesions...
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