Article
Generation of mice with inactivated Rh or Rhag genes.
Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine - 1 Jan 2000
Goossens D, Bony V, Gane P, Colin Y, Cartron J-P
Abstract excerpt
Mice carrying inactivated Rh and Rhag genes were generated by insertional targeting. KO animals exhibited normal growth, development and fertility and both types were indistinguishable at a gross phenotypic level from their wild type littermates. Preliminary analysis revealed that red cells from Rh-/- mice lack Rh protein and have a moderate decrease of Rhag protein, whereas those from Rhag-/- mice have a total...
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