Article
Novel RHAG allele encoding the Rh(null) phenotype in Brazil.
Transfusion - 1 Oct 2015
Arnoni Carine Prisco, Muniz Janaína Guilhem, Gazito Diana, Person Rosangela de Medeiros, Vendrame Tatiane Aparecida de Paula, Castilho Lilian, Latini Flavia Roche Moreira
Abstract excerpt
Rhnull is a rare phenotype characterized by the loss of Rh antigen expression. This phenotype can be related to several molecular backgrounds. In this study, we show a novel allele in a Brazilian pregnant woman encoding the Rhnull phenotype due to a change in RHAG exon2 c.310C>T, which leads to a premature stop codon (Gln104Stop).
Topics
- Alleles
- Blood Proteins
- Brazil
- Codon, Terminator
- Exons
- Female
- Humans
- Membrane Glycoproteins
- Pregnancy