Article
COL1A1 Sp1 polymorphism associates with bone density in early puberty.
Bone - 1 Sept 2006
Suuriniemi Miia, Kovanen Vuokko, Mahonen Anitta, Alén Markku, Wang Qingju, Lyytikäinen Arja, Cheng Sulin
Abstract excerpt
Optimal acquisition of bone mass in puberty is a key determinant of the lifetime risk of osteoporosis and has a strong genetic basis. We investigated the relationship between the COL1A1 Sp1 polymorphism and BMD in early puberty, and how the genotypes relate to bone size and geometry as well as bone turnover and material properties in 247 10- to 13-year-old girls. Bone properties were measured using DXA, pQCT, and...
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