Article
Cyclic-diGMP signal transduction systems in Vibrio cholerae: modulation of rugosity and biofilm formation.
Molecular microbiology - 1 Apr 2006
Lim Bentley, Beyhan Sinem, Meir James, Yildiz Fitnat H
Abstract excerpt
Cyclic di-guanylic acid (c-diGMP) is a second messenger that modulates the cell surface properties of several microorganisms. Concentrations of c-diGMP in the cell are controlled by the opposing activities of diguanylate cyclases and phosphodiesterases, which are carried out by proteins harbouring GGDEF and EAL domains respectively. In this study, we report that the cellular levels of c-diGMP are higher in the...
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