Regulation of rugosity and biofilm formation in Vibrio cholerae: comparison of VpsT and VpsR regulons and epistasis analysis of vpsT, vpsR, and hapR.

Abstract excerpt

Vibrio cholerae undergoes phenotypic variation that generates two morphologically different variants, termed smooth and rugose. The transcriptional profiles of the two variants differ greatly, and many of the differentially regulated genes are controlled by a complex regulatory circuitry that includes the transcriptional regulators VpsR, VpsT, and HapR. In this study, we identified the VpsT regulon and compared...

Topics

• Bacterial Proteins
• Biofilms
• Epigenesis, Genetic
• Gene Expression Regulation, Bacterial
• Genes, Bacterial
• Mutation
• Regulon
• Reverse Transcriptase Polymerase Chain Reaction
• Transcription, Genetic
• Vibrio cholerae
• Virulence