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Article

The Mycobacterium tuberculosis PhoPR two-component system regulates genes essential for virulence and complex lipid biosynthesis.

Molecular microbiology - 1 Apr 2006

Walters Shaun B, Dubnau Eugenie, Kolesnikova Irina, Laval Francoise, Daffe Mamadou, Smith Issar

Abstract excerpt

Two-component signal transduction systems (2-CS) play an important role in bacterial pathogenesis. In the work presented here, we have studied the effects of a mutation in the Mycobacterium tuberculosis (Mtb) PhoPR 2-CS on the pathogenicity, physiology and global gene expression of this bacterial pathogen. Disruption of PhoPR causes a marked attenuation of growth in macrophages and mice and prevents growth in...

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Identifiers

PMID: 16573683
DOI: 10.1111/j.1365-2958.2006.05102.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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