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Article

DNA mismatch repair and the significance of a sebaceous skin tumor for visceral cancer prevention.

Trends in molecular medicine - 1 Mar 2004

Kruse Roland, Ruzicka Thomas

Abstract excerpt

DNA mismatch repair is a postreplicative DNA repair cascade ensuring genomic integrity. Inactivating germline mutations in DNA mismatch repair genes are responsible for hereditary non-polyposis colorectal carcinoma syndrome (HNPCC), which predisposes to various types of visceral cancer. Most associated tumors exhibit high-grade microsatellite instability. Some patients develop skin tumors of the sebaceous glands....

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Share to Adaptor Proteins, Signal Transducing
Share to Base Pair Mismatch
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colorectal Neoplasms, Hereditary Nonpolyposis

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Identifiers

PMID: 15102357
DOI: 10.1016/j.molmed.2004.01.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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