Article
Interleukin 2 prevents graft-versus-host disease while preserving the graft-versus-leukemia effect of allogeneic T cells.
Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 1990
Sykes M, Romick M L, Sachs D H
Abstract excerpt
We have recently demonstrated that interleukin 2 (IL-2), when administered in high doses for several days beginning on the day of allogeneic bone marrow transplantation (BMT), markedly diminishes graft-versus-host disease (GVHD) mortality in lethally irradiated mice. An optimal anti-GVHD effect was attained by coadministering T-cell-depleted (TCD) syngeneic marrow. We demonstrate here that the full...
Topics
- Animals
- Antibodies, Monoclonal
- Bone Marrow Transplantation
- Female
- Graft vs Host Disease
- Interleukin-2
- Leukemia, Experimental
- Lymphocyte Depletion
- Lymphocytes
- Mice
- Mice, Inbred A