Article
Impaired T cell signal transduction through CD28 in a patient with idiopathic thrombocytopenia.
Clinical and experimental immunology - 1 Sept 1991
Pérez-Blas M, Arnaiz-Villena A, Góngora R, Segurado O G, Vivanco J L, Regueiro J R
Abstract excerpt
We describe an infant whose peripheral blood mononuclear cells were unable to proliferate or synthesize IL-2 in response to a mitogenic combination of antibodies directed against CD2 and CD28. This peculiar defect, which has been stable to date, was attributed to an impairment in CD28-mediated T cell activation, because further comitogenic combinations containing anti-CD28 monoclonals also failed to induce normal...
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