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Article

Impaired T cell signal transduction through CD28 in a patient with idiopathic thrombocytopenia.

Clinical and experimental immunology - 1 Sept 1991

Pérez-Blas M, Arnaiz-Villena A, Góngora R, Segurado O G, Vivanco J L, Regueiro J R

Abstract excerpt

We describe an infant whose peripheral blood mononuclear cells were unable to proliferate or synthesize IL-2 in response to a mitogenic combination of antibodies directed against CD2 and CD28. This peculiar defect, which has been stable to date, was attributed to an impairment in CD28-mediated T...

Topics

Antigens, Differentiation, T-Lymphocyte
CD28 Antigens
Humans
Infant
Lymphocyte Activation
Male
Monocytes
Phenotype
Signal Transduction
T-Lymphocytes
Thrombocytopenia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 1654236
DOI: 10.1111/j.1365-2249.1991.tb05743.x
PMCID: PMC1535620

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1654236-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Impaired T cell signal transduction through CD28 in a patient with idiopathic thrombocytopenia.PMID 1654236Read ↗

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