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Article

Role of P53-Senescence Induction in Suppression of LNCaP Prostate Cancer Growth by Cardiotonic Compound Bufalin.

Molecular cancer therapeutics - 1 Nov 2018

Zhang Yong, Dong Yinhui, Melkus Michael W, Yin Shutao, Tang Su-Ni, Jiang Peixin, Pramanik Kartick, Wu Wei, Kim Sangyub, Ye Min, Hu Hongbo, Lu Junxuan, Jiang Cheng

Abstract excerpt

Bufalin is a major cardiotonic compound in the traditional Chinese medicine, Chansu, prepared from toad skin secretions. Cell culture studies have suggested an anticancer potential involving multiple cellular processes, including differentiation, apoptosis, senescence, and angiogenesis. In prostate cancer cell models, P53-dependent and independent caspase-mediated apoptosis and androgen receptor (AR) antagonism...

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Identifiers

PMID: 30166403
DOI: 10.1158/1535-7163.MCT-17-1296
PMCID: PMC6668018

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SRC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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