Article
Myotonia and neuromuscular transmission in the mouse.
Muscle & nerve - 1 Aug 1991
Költgen D, Brinkmeier H, Jockusch H
Abstract excerpt
The role of neuromuscular transmission and acetylcholine receptors in the phenotypic expression of hereditary myotonia was reinvestigated in two mutants of the mouse, ADR (adr/adr) and MTO (adrmto/adrmto). Three neuromuscular blockers, curare, flaxedil, and alpha-bungarotoxin, did not prevent mechanical myotonia of EDL and soleus muscles from the two mutants. Furthermore, electrical myotonia was demonstrated in...
Topics
- Animals
- Bungarotoxins
- Curare
- Disease Models, Animal
- Gallamine Triethiodide
- Mice
- Mice, Mutant Strains
- Muscle Contraction
- Muscular Dystrophy, Animal
- Myotonia
- Neuromuscular Junction
- Phenotype