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Human methylenetetrahydrofolate reductase pharmacogenomics: gene resequencing and functional genomics.

Pharmacogenetics and genomics - 1 Apr 2006

Martin Yvette N, Salavaggione Oreste E, Eckloff Bruce W, Wieben Eric D, Schaid Daniel J, Weinshilboum Richard M

Abstract excerpt

5,10-Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme in the folate metabolic pathway. Common genetic polymorphisms in the human MTHFR gene are associated with individual variation in the efficacy and toxicity of chemotherapeutic agents, such as methotrexate and 5-fluorouracil. However, the full range of polymorphisms and intragene haplotypes in the human MTHFR gene remains unclear. Furthermore,...

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PMID: 16538173
DOI: 10.1097/01.fpc.0000194423.20393.08

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MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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