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Article

Fixation of mutations at the VP1 gene of foot-and-mouth disease virus. Can quasispecies define a transient molecular clock?

Gene - 22 Jul 1991

Villaverde A, Martínez M A, Sobrino F, Dopazo J, Moya A, Domingo E

Abstract excerpt

The number of nucleotide (nt) substitutions found in the VP1 gene (encoding viral capsid protein) between any two of 16 closely related isolates of foot-and-mouth disease virus (FMDV) has been quantified as a function of the time interval between isolations [Villaverde et al., J. Mol. Biol. 204 (1988) 771-776]. One of them (isolate C-S12) includes some replacements found in isolates that preceded it and other...

Topics

Amino Acid Sequence
Aphthovirus
Base Sequence
Biological Evolution
Capsid
Capsid Proteins
Kinetics
Molecular Sequence Data
Mutation
Sequence Alignment

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Identifiers

PMID: 1653754
DOI: 10.1016/0378-1119(91)90267-f

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1653754-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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