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Article

Engineering RNA interference-based resistance to dengue virus type 2 in genetically modified Aedes aegypti.

Proceedings of the National Academy of Sciences of the United States of America - 14 Mar 2006

Franz Alexander W E, Sanchez-Vargas Irma, Adelman Zach N, Blair Carol D, Beaty Barry J, James Anthony A, Olson Ken E

Abstract excerpt

Mosquitoes (Aedes aegypti) were genetically modified to exhibit impaired vector competence for dengue type 2 viruses (DENV-2). We exploited the natural antiviral RNA interference (RNAi) pathway in the mosquito midgut by constructing an effector gene that expresses an inverted-repeat (IR) RNA derived from the premembrane protein coding region of the DENV-2 RNA genome. The A. aegypti carboxypeptidase A promoter was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16537508
DOI: 10.1073/pnas.0600479103
PMCID: PMC1449670

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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