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Article

Genetically Engineered Resistance to Dengue-2 Virus Transmission in Mosquitoes

10 May 1996

Abstract excerpt

The control of arthropod-borne virus diseases such as dengue may ultimately require the genetic manipulation of mosquito vectors to disrupt virus transmission to human populations. To reduce the ability of mosquitoes to transmit dengue viruses, a recombinant Sindbis virus was used to transduce female Aedes aegypti with a 567-base antisense RNA targeted to the premembrane coding region of dengue type 2 (DEN-2)...

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Identifiers

PMID: 8629025
DOI: 10.1126/science.272.5263.884

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