Article
The Escherichia coli BarA-UvrY two-component system is a virulence determinant in the urinary tract.
BMC microbiology - 10 Mar 2006
Tomenius Henrik, Pernestig Anna-Karin, Jonas Kristina, Georgellis Dimitris, Möllby Roland, Normark Staffan, Melefors Ojar
Abstract excerpt
BACKGROUND: The Salmonella enterica BarA-SirA, the Erwinia carotovora ExpS-ExpA, the Vibrio cholerae BarA-VarA and the Pseudomonas spp GacS-GacA all belong to the same orthologous family of two-component systems as the Escherichia coli BarA-UvrY. In the first four species it has been demonstrated that disruption of this two-component system leads to a clear reduction in virulence of the bacteria. Our aim was to...
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