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Article

Coffee, CYP1A2 genotype, and risk of myocardial infarction.

JAMA - 8 Mar 2006

Cornelis Marilyn C, El-Sohemy Ahmed, Kabagambe Edmond K, Campos Hannia

Abstract excerpt

CONTEXT: The association between coffee intake and risk of myocardial infarction (MI) remains controversial. Coffee is a major source of caffeine, which is metabolized by the polymorphic cytochrome P450 1A2 (CYP1A2) enzyme. Individuals who are homozygous for the CYP1A2*1A allele are "rapid" caffeine metabolizers, whereas carriers of the variant CYP1A2*1F are "slow" caffeine metabolizers. OBJECTIVE: To determine...

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Identifiers

PMID: 16522833
DOI: 10.1001/jama.295.10.1135

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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