Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcript analysis reveals an extended regulon and the importance of protein-protein co-operativity for the Escherichia coli methionine repressor.

The Biochemical journal - 1 Jun 2006

Marincs Ferenc, Manfield Iain W, Stead Jonathan A, McDowall Kenneth J, Stockley Peter G

Abstract excerpt

We have used DNA arrays to investigate the effects of knocking out the methionine repressor gene, metJ, on the Escherichia coli transcriptome. We assayed the effects in the knockout strain of supplying wild-type or mutant MetJ repressors from an expression plasmid, thus establishing a rapid assay for in vivo effects of mutations characterized previously in vitro. Repression is largely restricted to known genes...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Escherichia coli Proteins
Share to Oligonucleotide Array Sequence Analysis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Operator Regions, Genetic

Share to Protein Structure, Quaternary

Share to Regulon

Share to Repressor Proteins

Share to Transcription, Genetic

Share to Tryptophan

Source

Open in PubMed Open full text

Identifiers

PMID: 16515535
DOI: 10.1042/BJ20060021
PMCID: PMC1462706

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcript analysis reveals an extended regulon and the importance of protein-protein co-operativity for the Escherichia coli methionine repressor.PMID 16515535Read ↗

Mapping the phenotypic landscape of a transcriptional repressor using deep mutational scanning and growth-based quantitative sequencing.Semantic proximity Read ↗

Kinetic analysis of operator binding by the E. coli methionine repressor highlights the role(s) of electrostatic interactions.Semantic proximity Read ↗

The Escherichia coli K-12 metJ193 allele contains a point mutation which alters the hydrophobic pocket responsible for in vitro binding of S-adenosylmethionine: effects on cell growth and induction of met regulon expression.Semantic proximity Read ↗

Functional rules for lac repressor-operator associations and implications for protein-DNA interactions.Semantic proximity Read ↗

ArgR-dependent repression of arginine and histidine transport genes in Escherichia coli K-12.Semantic proximity Read ↗

Transcription regulation coupling of the divergent argG and metY promoters in Escherichia coli K-12.Semantic proximity Read ↗

The lactose repressor system: paradigms for regulation, allosteric behavior and protein folding.Semantic proximity Read ↗

Protein signatures that promote operator selectivity among paralog MerR monovalent metal ion regulators.Semantic proximity Read ↗

DNA microarray analysis of fim mutations in Escherichia coli.Semantic proximity Read ↗

Exploring the sequence-function relationship in transcriptional regulation by the lac O1 operator.Semantic proximity Read ↗

Escherichia coli metR mutants that produce a MetR activator protein with an altered homocysteine response.Semantic proximity Read ↗

Substitutions in the periplasmic domain of low-abundance chemoreceptor trg that induce or reduce transmembrane signaling: kinase activation and context effects.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.