Article
Coexpression of voltage-dependent calcium channels Cav1.2, 2.1a, and 2.1b in vascular myocytes.
Hypertension (Dallas, Tex. : 1979) - 1 Apr 2006
Andreasen Ditte, Friis Ulla G, Uhrenholt Torben R, Jensen Boye L, Skøtt Ole, Hansen Pernille B
Abstract excerpt
Voltage-dependent Ca2+ channels Cav1.2 (L type) and Cav2.1 (P/Q type) are expressed in vascular smooth muscle cells (VSMCs) and are important for the contraction of renal resistance vessels. In the present study we examined whether native renal VSMCs coexpress L-, P-, and Q-type Ca2+ currents. The expression of both Cav2.1a (P-type) and Cav2.1b (Q-type) mRNA was demonstrated by RT-PCR in renal preglomerular...
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