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Article

Positive association between POU1F1 and mental retardation in young females in the Chinese Han population.

Human molecular genetics - 1 Apr 2006

Sun Yun, Zhang Fuchang, Gao Jianjun, Gao Xiaocai, Guo Tingwei, Zhang Kejin, Shi Yongyong, Zheng Zijian, Tang Wei, Zheng Yonglan, Li Sheng, Li Xingwang, Feng Guoyin, Shen Xiaoming, He Lin

Abstract excerpt

Genetic defects attributable to the genes involved in the hypothalamus-pituitary-thyroid (HPT) gland axis can cause abnormal thyroid hormone function and mental retardation (MR). Pit-1, encoded by the POU1F1 gene on human chromosome 3p11, is a pituitary-specific transcription factor responsible for the expression of several pituitary hormones. Thyrotropin is one of these hormones and is an important regulator in...

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PMID: 16505001
DOI: 10.1093/hmg/ddl039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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