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Article

Assessment of structure and function over a 3-year period after gene transfer in RPE65-/- dogs.

Documenta ophthalmologica. Advances in ophthalmology - 1 Jul 2005

Narfström Kristina, Vaegan, Katz Martin, Bragadottir Ragnheidur, Rakoczy Elizabeth P, Seeliger Mathias

Abstract excerpt

AIM: To assess retinal structure and function over a 3-year period in a group of five RPE65-/- dogs treated by unilateral rAAV- mediated subretinal gene transfer. METHODS: Post-operative functional follow-ups were performed using simultaneous, bilateral, full-field ERGs. Structure was evaluated by SLO using FL and ICG angiography and by EM. RESULTS: Significant improvement of retinal function was observed through...

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Source

Identifiers

PMID: 16502306
DOI: 10.1007/s10633-005-3159-0

Genes

RPE65

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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