Synergistic topical therapy by acyclovir and A1110U for herpes simplex virus induced zosteriform rash in mice.

doi:10.1016/0166-3542(91)90027-o

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Article

Synergistic topical therapy by acyclovir and A1110U for herpes simplex virus induced zosteriform rash in mice.

Antiviral research - 1 Feb 1991

Lobe D C, Spector T, Ellis M N

Abstract excerpt

Combination therapy with A1110U, an inactivator of the herpes simplex virus (HSV) and the varicella zoster virus ribonucleotide reductase, and acyclovir (ACV) was evaluated for treatment of cutaneous herpetic disease in athymic mice infected on the dorsum. In this model, infection with HSV produc...

Topics

Acyclovir
Administration, Topical
Animals
Drug Resistance, Microbial
Drug Synergism
Drug Therapy, Combination
Female
Herpes Simplex
Hydrazones
Mice
Mice, Inbred BALB C
Mice, Nude
Mutation
Pyridines
Ribonucleotide Reductases
Simplexvirus

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