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Identification of a novel specific CYP2B6 allele in Africans causing impaired metabolism of the HIV drug efavirenz.

Pharmacogenetics and genomics - 1 Mar 2006

Wang Jue, Sönnerborg Anders, Rane Anders, Josephson Filip, Lundgren Stefan, Ståhle Lars, Ingelman-Sundberg Magnus

Abstract excerpt

The non-nucleoside reverse transcriptase inhibitor efavirenz is mainly metabolised by the polymorphic cytochrome P450 enzyme CYP2B6. Genomic DNA from four subjects in a group of 51 patients being treated with efavirenz and having surprisingly high plasma concentrations were screened by direct seq...

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PMID: 16495778
DOI: 10.1097/01.fpc.0000189797.03845.90

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16495778-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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