Article
Regulation of growth differentiation factor 9 expression in oocytes in vivo: a key role of the E-box.
Biology of reproduction - 1 Jun 2006
Yan Changning, Elvin Julia A, Lin Yi-Nan, Hadsell Lou Ann, Wang Jie, DeMayo Francesco J, Matzuk Martin M
Abstract excerpt
Growth differentiation factor 9 (GDF9) is preferentially expressed in oocytes and is essential for female fertility. To identify regulatory elements that confer high-level expression of GDF9 in the ovary but repression in other tissues, we generated transgenic mice in which regions of the Gdf9 lo...
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