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Loss of growth differentiation factor 9 causes an arrest of early folliculogenesis in zebrafish–A novel insight into its action mechanism

15 Dec 2022

Abstract excerpt

Growth differentiation factor 9 (GDF9) was the first oocyte-specific growth factor identified; however, most information about GDF9 functions comes from studies in the mouse model. In this study, we created a mutant for Gdf9 gene (gdf9-/-) in zebrafish using TALEN approach. The loss of Gdf9 caused a complete arrest of follicle development at primary growth (PG) stage. These follicles eventually degenerated, and...

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PMID: 36520929
DOI: 10.1371/journal.pgen.1010318

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