Article
TEDS site phosphorylation of the yeast myosins I is required for ligand-induced but not for constitutive endocytosis of the G protein-coupled receptor Ste2p.
The Journal of biological chemistry - 21 Apr 2006
Grosshans Bianka L, Grötsch Helga, Mukhopadhyay Debdyuti, Fernández Isabel M, Pfannstiel Jens, Idrissi Fatima-Zahra, Lechner Johannes, Riezman Howard, Geli M Isabel
Abstract excerpt
The yeast myosins I Myo3p and Myo5p have well established functions in the polarization of the actin cytoskeleton and in the endocytic uptake of the G protein-coupled receptor Ste2p. A number of results suggest that phosphorylation of the conserved TEDS serine of the myosin I motor head by the Cdc42p activated p21-activated kinases Ste20p and Cla4p is required for the organization of the actin cytoskeleton....
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