Article
Higher activity of polymorphic NAD(P)H:quinone oxidoreductase in liver cytosols from blacks compared to whites.
Toxicology letters - 14 Jul 2006
Covarrubias Vanessa Gonzalez, Lakhman Sukhwinder S, Forrest Alan, Relling Mary V, Blanco Javier G
Abstract excerpt
In human liver, the two-electron reduction of quinone compounds, such as menadione is catalyzed by cytosolic carbonyl reductase (CBR) and NAD(P)H:quinone oxidoreductase (NQO1) activities. We assessed the relative contributions of CBR and NQO1 activities to the total menadione reducing capacity in liver cytosols from black (n=31) and white donors (n=63). Maximal menadione reductase activities did not differ...
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