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Article

Neurotrophin-4/5-depletion induces a delay in maturation of the periodontal Ruffini endings in mice.

Archives of histology and cytology - 1 Dec 2005

Maruyama Yuko, Harada Fumiko, Jabbar Shahiqul, Saito Isao, Aita Megumi, Kawano Yoshiro, Suzuki Akiko, Nozawa-Inoue Kayoko, Maeda Takeyasu

Abstract excerpt

Neurotrophin-4/5 (NT-4/5) - a member of the neurotrophic factors - is a ligand for TrkB, which has been reported to be expressed in the mechanoreceptive Ruffini endings of the periodontal ligament. The present study examined developmental changes in the terminal morphology and neural density in homozygous mice with a targeted disruption of the nt-4/5 gene and wild-type mice by immunohistochemistry for protein...

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Source

Identifiers

PMID: 16477147
DOI: 10.1679/aohc.68.267

Genes

NGFR
PGP
BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Neurotrophin-4/5-depletion induces a delay in maturation of the periodontal Ruffini endings in mice.PMID 16477147Read ↗

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