Article
Involvement of brain-derived neurotrophic factor (BDNF) in the development of periodontal Ruffini endings.
The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology - 1 Sept 2003
Hoshino Natalia, Harada Fumiko, Alkhamrah Bashar Anas, Aita Megumi, Kawano Yoshiro, Hanada Kooji, Maeda Takeyasu
Abstract excerpt
The periodontal Ruffini ending has been reported to show immunoreactivity for tyrosine kinase B (trkB), the high-affinity receptor for brain-derived neurotrophic factor (BDNF), in the periodontal ligament of the rat incisor. Furthermore, adult heterozygous BDNF-mutant mice showed malformation and reduction of the periodontal Ruffini endings. To investigate further roles of BDNF in these structures, the...
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