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Detailed analysis of the E2-IgM complex in hepatitis C-related type II mixed cryoglobulinaemia.

Journal of viral hepatitis - 1 Mar 2006

Ferri S, Dal Pero F, Bortoletto G, Bianchi F B, Lenzi M, Alberti A, Gerotto M

Abstract excerpt

Hepatitis C virus (HCV) plays a major role in the induction of type II mixed cryoglobulinaemia (MCII). The role of HCV proteins and virus-host interaction in the pathogenesis of MC remains to be defined. To address this issue, we have characterized, in detail, the monoclonal IgM and the viral component of circulating immune complexes in eight patients with HCV-associated MCII. The proportion of HCV-RNA...

Topics

Aged
Amino Acid Sequence
Antigen-Antibody Complex
Complementarity Determining Regions
Cryoglobulinemia
Female
Hepatitis C
Humans
Immunoglobulin M
Immunoglobulin Variable Region
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Mutation

RNA, Viral

Sequence Alignment

Viral Envelope Proteins

Source

Identifiers

PMID: 16475992
DOI: 10.1111/j.1365-2893.2005.00675.x

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