Article
Use of competitive DNA hybridization to identify differences in the genomes of bacteria.
Journal of microbiological methods - 1 Aug 2006
Shanks Orin C, Santo Domingo Jorge W, Graham James E
Abstract excerpt
Although recent technological advances in DNA sequencing and computational biology now allow scientists to compare entire microbial genomes, comparisons of closely related bacterial species and individual isolates by whole-genome sequencing approaches remains prohibitively expensive for most laboratories. Here we report the development and testing of a biochemical approach for targeted sequencing of only those...
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