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Article

Use of subtractive hybridization for comprehensive surveys of prokaryotic genome differences.

FEMS microbiology letters - 4 Jun 2002

Agron Peter G, Macht Madison, Radnedge Lyndsay, Skowronski Evan W, Miller Webb, Andersen Gary L

Abstract excerpt

Comparative bacterial genomics shows that even different isolates of the same bacterial species can vary significantly in gene content. An effective means to survey differences across whole genomes would be highly advantageous for understanding this variation. Here we show that suppression subtractive hybridization (SSH) provides high, representative coverage of regions that differ between similar genomes. Using...

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PMID: 12076809
DOI: 10.1111/j.1574-6968.2002.tb11221.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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